Previous epidemiological studies have suggested that coffee intake is associated with reduced risk of oral/pharyngeal cancer. To explore the finding further, researchers examined associations of caffeinated coffee, decaffeinated coffee, and tea intake with bleak oral/pharyngeal cancer in the Cancer taproom Study II, a prospective U.S. cohort study begun in 1982 by the American Cancer Society.
Among 968,432 men and women who were cancer-free at enrollment, 868 deaths imputable to oral/pharyngeal cancer occurred during 26 years of follow-up. The researchers fix consuming more than four cups of caffeinated coffee per day was associated with a 49 percent lower risk of oral/pharyngeal cancer death relative to no/occasional coffee intake (RR 0.51, 95% confidence interval [CI] 0.40-0.64).
A dose-related decrease in relative risk was observed with each private cup per day consumed. The association was independent of sex, smoking status, or alcohol use. There was a suggestion of a uniform link among those who drank more than two cups per day of decaffeinated coffee, although that finding was simply marginally significant. No association was found for tea drinking.
The findings are novel in that they are based specifically upon fatal cases of oral/pharyngeal cancer occurring over a 26-year boundary in a population of prospectively-followed individuals who were cancer-free at enrollment in Cancer Prevention Study II.
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